Biochemist's songbook - PRAISE OF GLYCOLYSIS (TUNE:“THE BRITISH GRENADIERS”) | Текст песни

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• Biochemist's songbook
• PRAISE OF GLYCOLYSIS (TUNE:“THE BRITISH GRENADIERS”)

Some pathways lead to glory, like Hatch and Slack and Knoop,
Utter, Calvin, Cori -- a most distinguished group,
But of all of nature's pathways, we sing the praise today
Of Embden, Meyerhof, Parnas -- the glycolytic way.

Glucose, by hexokinase is turned to G6P
(You might use glucokinase, you must use ATP)
And, note, glycogenolysis (when stores are in the cell)
Gives G1P which then mutates to G6P as well.

The moiety of glucose, in the succeeding phase
Is transferred to a ketose by an isomerase
Phosphofructokinase now, acts on that F6P;
Fructose 1,6 bisphosphate is the product that's set free.

The kinase is effected quite complicatedly
And as you'll have suspected it uses ATP;
FBP by aldolase is split reversibly
To phosphoglyceraldehyde, also DHAP.

The former and the latter can each equilibrate --
It really doesn't matter for metabolic fate --
So follow PG aldehyde and double what you see,
You'll get the total balance sheet for a hexose moiety.

There's now a novel facet, for NAD's reduced
But carboxylic acid is not what is produced,
Delta-G's substantial, and energy's conserved
(For otherwise the pathway would, quite frankly, be absurd).

The complex oxidation of PG aldehyde
Gives by phosphorylation an acid anhydride,
And that bisphosphoglycerate reacts with ADP
The kinase making ATP, of course reversibly.

The product's composition, 3-phosphoglycerate
From 3 to 2 position can readily mutate
And now 2-phosphoglycerate does something rather strange --
Electrons on C2 and 3 proceed to rearrange.

This redox-dehydration, catalyzed by enolase
Gives PEP formation and bond energy raise
So phosphoenol pyruvate reacts with ADP
The kinase making ATP, but not reversibly.

In anaerobiosis, pyruvate's not the end;
The problem we suppose is not hard to comprehend;
The dehydrogenation to phosphoglycerate
Would grind to halt if NAD could not regenrate.

The answer is quite subtle, pyruvate is reduced,
Instead of glycerol shuttle, lactate is produced;
Lactate dehydrogenase performs that noble feat,
NADH is oxidized, the pathway is complete.

The balance sheet you'll see shows transfer of energy,
Two ATP's from glucose and three from G1P.
That's good, but oh to use the way where puryvate's reduced
With decarboxylation first, then enthanol produced!


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