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Metabolic Songs - Waltz Around The Cycle | Текст песни

Once a jolly pyruvate enters the matrix
Of a mitochondrion, so they say,
A decarboxylating, complex dehydrogenase
Converts it to acetyl co-enzyme A.

Waltz around the cycle
Waltz around the cycle
Waltz around the TCA cycle today
A decarboxylating, complex dehydrogenase
Turns a pyruvate to acetyl-CoA

Oxaloacetate looking for a partner
Thinks, "active acetate looks OK";
Condensing enzyme arranging for a merger
Makes a new citrate and kicks out CoA.

Waltz around the cycle
Waltz around the cycle
Waltz around the TCA cycle today
Condensing enzyme arranging a merger
Makes a new citrate and kicks out CoA

Along comes aconitase, a hydro-dehydratase
Gives isocitrate reversibly
Then its dehydrogenase gives NADH,
Carbon dioxide and (alpha)-OG.

Waltz around the cycle
Waltz around the cycle
Waltz around the TCA cycle with me
Then its dehydrogenase gives NADH,
Carbon dioxide and (alpha)-OG.

Off with the CO2, another oxidation
Just like the PDC previously
Succinyl CoA with a thiokinase
Yields succinate and GTP.

Waltz around the cycle
Waltz around the cycle
Waltz around the TCA cycle with me
Succinyl CoA with a thiokinase
Yields succinate and GTP.

Succinate's oxidised by its dehydrogenase
Reducing FAD and giving fumerate
Fumarase makes malate; another dehydrogenase
Generates oxaloacetate.

Waltz around the cycle
Waltz around the cycle
Waltz around the TCA cycle with me
Fumarase makes malate; another dehydrogenase
Generates oxaloacetate.

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