Once a jolly pyruvate enters the matrix Of a mitochondrion, so they say, A decarboxylating, complex dehydrogenase Converts it to acetyl co-enzyme A.
Waltz around the cycle Waltz around the cycle Waltz around the TCA cycle today A decarboxylating, complex dehydrogenase Turns a pyruvate to acetyl-CoA
Oxaloacetate looking for a partner Thinks, "active acetate looks OK"; Condensing enzyme arranging for a merger Makes a new citrate and kicks out CoA.
Waltz around the cycle Waltz around the cycle Waltz around the TCA cycle today Condensing enzyme arranging a merger Makes a new citrate and kicks out CoA
Along comes aconitase, a hydro-dehydratase Gives isocitrate reversibly Then its dehydrogenase gives NADH, Carbon dioxide and (alpha)-OG.
Waltz around the cycle Waltz around the cycle Waltz around the TCA cycle with me Then its dehydrogenase gives NADH, Carbon dioxide and (alpha)-OG.
Off with the CO2, another oxidation Just like the PDC previously Succinyl CoA with a thiokinase Yields succinate and GTP.
Waltz around the cycle Waltz around the cycle Waltz around the TCA cycle with me Succinyl CoA with a thiokinase Yields succinate and GTP.
Succinate's oxidised by its dehydrogenase Reducing FAD and giving fumerate Fumarase makes malate; another dehydrogenase Generates oxaloacetate.
Waltz around the cycle Waltz around the cycle Waltz around the TCA cycle with me Fumarase makes malate; another dehydrogenase Generates oxaloacetate.